Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50511839 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1845690 (CHEMBL4346117) |
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IC50 | 67±n/a nM |
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Citation | Li, X; Jiang, Y; Peterson, YK; Xu, T; Himes, RA; Luo, X; Yin, G; Inks, ES; Dolloff, N; Halene, S; Chan, SSL; Chou, CJ Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity. J Med Chem63:5501-5525 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50511839 |
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n/a |
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Name | BDBM50511839 |
Synonyms: | CHEMBL4534191 |
Type | Small organic molecule |
Emp. Form. | C17H21N3O |
Mol. Mass. | 283.3681 |
SMILES | CCCNNC(=O)c1ccc(NCc2ccccc2)cc1 |
Structure |
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