Reaction Details |
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Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
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Ligand | BDBM168281 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1849895 (CHEMBL4350436) |
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IC50 | 1.5±n/a nM |
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Citation | Abdelaziz, AM; Basnet, SKC; Islam, S; Li, M; Tadesse, S; Albrecht, H; Gerber, C; Yu, M; Wang, S Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione derivatives as Mnk inhibitors. Bioorg Med Chem Lett29:2650-2654 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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MAP kinase-interacting serine/threonine-protein kinase 2 |
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Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
Type: | Protein |
Mol. Mass.: | 51870.79 |
Organism: | Homo sapiens (Human) |
Description: | Q9HBH9 |
Residue: | 465 |
Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
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BDBM168281 |
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n/a |
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Name | BDBM168281 |
Synonyms: | US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 109) |
Type | Small organic molecule |
Emp. Form. | C16H16ClN5O2 |
Mol. Mass. | 345.784 |
SMILES | Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1 |
Structure |
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