Reaction Details |
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Target | fMet-Leu-Phe receptor |
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Ligand | BDBM50513121 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1852059 (CHEMBL4352683) |
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EC50 | 8511±n/a nM |
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Citation | Deora, GS; Qin, CX; Vecchio, EA; Debono, AJ; Priebbenow, DL; Brady, RM; Beveridge, J; Teguh, SC; Deo, M; May, LT; Krippner, G; Ritchie, RH; Baell, JB Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists. J Med Chem62:5242-5248 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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fMet-Leu-Phe receptor |
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Name: | fMet-Leu-Phe receptor |
Synonyms: | FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38456.14 |
Organism: | Homo sapiens (Human) |
Description: | gi_4503779 |
Residue: | 350 |
Sequence: | METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVT
TISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIA
LDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNF
SPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPL
RVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPML
YVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
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BDBM50513121 |
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n/a |
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Name | BDBM50513121 |
Synonyms: | CHEMBL4569975 |
Type | Small organic molecule |
Emp. Form. | C22H22FN3O3 |
Mol. Mass. | 395.4268 |
SMILES | COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(F)cc3)c2=O)c1 |
Structure |
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