| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50069566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63362 |
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| IC50 | 160±n/a nM |
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| Citation |  Mederski, WW; Osswald, M; Dorsch, D; Anzali, S; Christadler, M; Schmitges, CJ; Wilm, C Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster. Bioorg Med Chem Lett8:17-22 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50069566 |
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| n/a |
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| Name | BDBM50069566 |
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| Synonyms: | 3-(4-Methoxy-phenyl)-1-(6-methyl-benzo[1,2,5]thiadiazol-5-ylmethyl)-5-propoxy-1H-indole-2-carboxylic acid | CHEMBL306863 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N3O4S |
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| Mol. Mass. | 487.57 |
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| SMILES | CCCOc1ccc2n(Cc3cc4nsnc4cc3C)c(C(O)=O)c(-c3ccc(OC)cc3)c2c1 |
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| Structure | 
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