| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50069568 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_63362 |
|---|
| IC50 | 1300±n/a nM |
|---|
| Citation |  Mederski, WW; Osswald, M; Dorsch, D; Anzali, S; Christadler, M; Schmitges, CJ; Wilm, C Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster. Bioorg Med Chem Lett8:17-22 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48256.91 |
|---|
| Organism: | RAT |
|---|
| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
|
|
|
|---|
| BDBM50069568 |
|---|
| n/a |
|---|
| Name | BDBM50069568 |
|---|
| Synonyms: | 1-Benzo[1,3]dioxol-5-ylmethyl-4-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-benzo[4,5]furo[3,2-b]pyridine-3-carboxylic acid | CHEMBL73506 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H19NO7 |
|---|
| Mol. Mass. | 469.4423 |
|---|
| SMILES | COc1ccc(cc1)-c1c(C(O)=O)c(=O)n(Cc2ccc3OCOc3c2)c2c3ccccc3oc12 |
|---|
| Structure | 
|
|---|
Search and Browse
