| Reaction Details |
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 | Report a problem with these data |
| Target | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2/G(I)/G(S)/G(T) subunit beta-1 |
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| Ligand | BDBM50444748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1856735 (CHEMBL4357464) |
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| IC50 | 5000±n/a nM |
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| Citation |  Li, J; Ge, Y; Huang, JX; Strømgaard, K; Zhang, X; Xiong, XF Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery. J Med Chem63:5013-5030 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2/G(I)/G(S)/G(T) subunit beta-1 |
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| Name: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2/G(I)/G(S)/G(T) subunit beta-1 |
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| Synonyms: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1856735 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
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| Synonyms: | GBB1_HUMAN | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Transducin beta chain 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37373.57 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117032 |
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| Residue: | 340 |
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| Sequence: | MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
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| Component 2 |
| Name: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 |
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| Synonyms: | G gamma-I | GBG2_HUMAN | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 7851.57 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117032 |
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| Residue: | 71 |
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| Sequence: | MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL
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| BDBM50444748 |
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| n/a |
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| Name | BDBM50444748 |
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| Synonyms: | Aminoquinuride |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N6O |
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| Mol. Mass. | 372.4231 |
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| SMILES | Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1 |
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| Structure | 
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