Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 4 |
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Ligand | BDBM50514929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1859084 (CHEMBL4359940) |
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Ki | 0.500000±n/a nM |
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Citation | Bryan, MC; Drobnick, J; Gobbi, A; Kolesnikov, A; Chen, Y; Rajapaksa, N; Ndubaku, C; Feng, J; Chang, W; Francis, R; Yu, C; Choo, EF; DeMent, K; Ran, Y; An, L; Emson, C; Huang, Z; Sujatha-Bhaskar, S; Brightbill, H; DiPasquale, A; Maher, J; Wai, J; McKenzie, BS; Lupardus, PJ; Zarrin, AA; Kiefer, JR Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J Med Chem62:6223-6240 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 4 |
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Name: | Interleukin-1 receptor-associated kinase 4 |
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
Type: | Protein |
Mol. Mass.: | 51519.08 |
Organism: | Homo sapiens (Human) |
Description: | Q9NWZ3 |
Residue: | 460 |
Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50514929 |
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n/a |
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Name | BDBM50514929 |
Synonyms: | CHEMBL4474636 |
Type | Small organic molecule |
Emp. Form. | C24H27N7O3S |
Mol. Mass. | 493.581 |
SMILES | OCC1CCN(CC1)c1cc2nc(sc2cc1NC(=O)c1cnn2cccnc12)N1CCOCC1 |
Structure |
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