| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fes/Fps |
|---|
| Ligand | BDBM50515040 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1859774 (CHEMBL4360630) |
|---|
| IC50 | 494±n/a nM |
|---|
| Citation |  Yuan, T; Qi, B; Jiang, Z; Dong, W; Zhong, L; Bai, L; Tong, R; Yu, J; Shi, J Dual FLT3 inhibitors: Against the drug resistance of acute myeloid leukemia in recent decade. Eur J Med Chem178:468-483 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Fes/Fps |
|---|
| Name: | Tyrosine-protein kinase Fes/Fps |
|---|
| Synonyms: | FES | FES_HUMAN | FPS | Tyrosine-protein kinase FES | Tyrosine-protein kinase Fes/Fps |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 93498.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07332 |
|---|
| Residue: | 822 |
|---|
| Sequence: | MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR
TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF
LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK
SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL
KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL
LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR
QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP
CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
|
|
|
|---|
| BDBM50515040 |
|---|
| n/a |
|---|
| Name | BDBM50515040 |
|---|
| Synonyms: | CHEMBL4474361 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31N7O4S |
|---|
| Mol. Mass. | 537.634 |
|---|
| SMILES | COc1cc(ccc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2cn[nH]c2n1)N1CCC(O)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
