| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-8 |
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| Ligand | BDBM50516221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1863868 (CHEMBL4364843) |
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| IC50 | 128±n/a nM |
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| Citation |  Zhan, W; Visone, J; Ouellette, T; Harris, JC; Wang, R; Zhang, H; Singh, PK; Ginn, J; Sukenick, G; Wong, TT; Okoro, JI; Scales, RM; Tumwebaze, PK; Rosenthal, PJ; Kafsack, BFC; Cooper, RA; Meinke, PT; Kirkman, LA; Lin, G Improvement of Asparagine Ethylenediamines as Anti-malarial J Med Chem62:6137-6145 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-8 |
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| Name: | Proteasome subunit beta type-8 |
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| Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30357.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446797 |
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| Residue: | 276 |
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| Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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| BDBM50516221 |
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| n/a |
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| Name | BDBM50516221 |
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| Synonyms: | CHEMBL4521059 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31FN4O5S |
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| Mol. Mass. | 506.59 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)N[C@@H](CC(=O)NC(C)(C)C)C(=O)NCCNC(=O)c1cccc(F)c1 |r| |
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| Structure | 
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