| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50516390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1864571 (CHEMBL4365546) |
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| IC50 | 580±n/a nM |
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| Citation |  Myers, SM; Miller, DC; Molyneux, L; Arasta, M; Bawn, RH; Blackburn, TJ; Cook, SJ; Edwards, N; Endicott, JA; Golding, BT; Griffin, RJ; Hammonds, T; Hardcastle, IR; Harnor, SJ; Heptinstall, AB; Lochhead, PA; Martin, MP; Martin, NC; Newell, DR; Owen, PJ; Pang, LC; Reuillon, T; Rigoreau, LJM; Thomas, HD; Tucker, JA; Wang, LZ; Wong, AC; Noble, MEM; Wedge, SR; Cano, C Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38? and BRD4. Eur J Med Chem178:530-543 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50516390 |
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| n/a |
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| Name | BDBM50516390 |
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| Synonyms: | CHEMBL4449117 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13F2N3O2 |
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| Mol. Mass. | 341.3115 |
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| SMILES | Fc1cccc(F)c1C(=O)c1c[nH]c(c1)C(=O)NCc1ccncc1 |
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| Structure | 
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