Reaction Details |
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Target | Menin |
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Ligand | BDBM50516547 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1865913 (CHEMBL4366888) |
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Ki | 22±n/a nM |
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Citation | Aguilar, A; Zheng, K; Xu, T; Xu, S; Huang, L; Fernandez-Salas, E; Liu, L; Bernard, D; Harvey, KP; Foster, C; McEachern, D; Stuckey, J; Chinnaswamy, K; Delproposto, J; Kampf, JW; Wang, S Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem62:6015-6034 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Menin |
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Name: | Menin |
Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
Type: | Protein |
Mol. Mass.: | 68022.55 |
Organism: | Homo sapiens (Human) |
Description: | O00255 |
Residue: | 610 |
Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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BDBM50516547 |
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n/a |
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Name | BDBM50516547 |
Synonyms: | CHEMBL4448045 | US10899738, Cpd. No 27 |
Type | Small organic molecule |
Emp. Form. | C29H37N3O |
Mol. Mass. | 443.6236 |
SMILES | N#Cc1ccc(OCCCN2CCC(CC2)C2(NCCc3ccccc23)C2CCCC2)cc1 |
Structure |
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