| Reaction Details |
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 | Report a problem with these data |
| Target | Menin |
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| Ligand | BDBM50516580 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1865913 (CHEMBL4366888) |
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| Ki | 350±n/a nM |
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| Citation |  Aguilar, A; Zheng, K; Xu, T; Xu, S; Huang, L; Fernandez-Salas, E; Liu, L; Bernard, D; Harvey, KP; Foster, C; McEachern, D; Stuckey, J; Chinnaswamy, K; Delproposto, J; Kampf, JW; Wang, S Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem62:6015-6034 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Menin |
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| Name: | Menin |
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| Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
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| Type: | Protein |
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| Mol. Mass.: | 68022.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00255 |
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| Residue: | 610 |
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| Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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| BDBM50516580 |
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| n/a |
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| Name | BDBM50516580 |
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| Synonyms: | CHEMBL4453547 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40N4O2 |
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| Mol. Mass. | 524.6963 |
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| SMILES | [H][C@@]1(CCC[C@@H]1OC(=O)CCC)[C@@](C#N)(C1CCN(CC2CN(C2)c2ccc(cc2)C#N)CC1)c1ccccc1 |r| |
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| Structure | 
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