| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM50516677 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1866461 (CHEMBL4367436) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Haile, PA; Casillas, LN; Votta, BJ; Wang, GZ; Charnley, AK; Dong, X; Bury, MJ; Romano, JJ; Mehlmann, JF; King, BW; Erhard, KF; Hanning, CR; Lipshutz, DB; Desai, BM; Capriotti, CA; Schaeffer, MC; Berger, SB; Mahajan, MK; Reilly, MA; Nagilla, R; Rivera, EJ; Sun, HH; Kenna, JK; Beal, AM; Ouellette, MT; Kelly, M; Stemp, G; Convery, MA; Vossenkämper, A; MacDonald, TT; Gough, PJ; Bertin, J; Marquis, RW Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[ J Med Chem62:6482-6494 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 2 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | Receptor-interacting serine/threonine-protein kinase 2 | Ripk2 | Tyrosine-protein kinase RIPK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60785.84 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_116814 |
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| Residue: | 539 |
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| Sequence: | MNGDAICSALPHIPYHKLADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSER
NDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPEIAWPL
RFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
YKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMY
SVSQGHRPNTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFEDI
TFLEAVIQLKKSKIQSASSTIHLCDKKMDLSLNIPASHPPQEESCGSSLLSRNAGSPGTS
RSLSAPQDKGFFHGGPQDCSSSKAYHCPGNHSWDGIISVSQEAAFCDRRASSCSLTVIRP
LLVEKSSERPQPGIAQQWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELISTKP
TRTAKVRQLLDTSDIQGEEFARVIVQKLKDNKQMGLQPYPEVLLVSRTPSSNVLQNKTL
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| BDBM50516677 |
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| n/a |
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| Name | BDBM50516677 |
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| Synonyms: | CHEMBL4514780 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N4O4S2 |
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| Mol. Mass. | 458.554 |
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| SMILES | CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCO |
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| Structure | 
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