| Reaction Details |
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 | Report a problem with these data |
| Target | Acetyl-coenzyme A synthetase, cytoplasmic |
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| Ligand | BDBM50517061 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1867284 (CHEMBL4368259) |
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| IC50 | 0.002800±n/a nM |
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| Citation |  Kargbo, RB Inhibition of ACSS2 for Treatment of Cancer and Neuropsychiatric Diseases. ACS Med Chem Lett10:1100-1101 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetyl-coenzyme A synthetase, cytoplasmic |
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| Name: | Acetyl-coenzyme A synthetase, cytoplasmic |
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| Synonyms: | 6.2.1.1 | 6.2.1.17 | ACAS2 | ACS | ACSA_HUMAN | ACSS2 | AceCS | AceCS1 | Acetate--CoA ligase | Acetyl-CoA synthetase | Acetyl-CoA synthetase 1 | Acetyl-coenzyme A synthetase, cytoplasmic | Acyl-CoA synthetase short-chain family member 2 | Acyl-activating enzyme | Propionate--CoA ligase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78577.73 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119217 |
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| Residue: | 701 |
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| Sequence: | MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
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| BDBM50517061 |
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| n/a |
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| Name | BDBM50517061 |
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| Synonyms: | CHEMBL4467131 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20F4N4O3 |
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| Mol. Mass. | 500.4449 |
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| SMILES | CC1=NN(C(=O)C1C(=O)Nc1cccc(c1)C(C)(F)F)c1ccc(OC(F)F)c(c1)-c1ccncc1 |t:1| |
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| Structure | 
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