| Reaction Details |
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 | Report a problem with these data |
| Target | Urotensin-2 receptor |
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| Ligand | BDBM50517318 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1868959 (CHEMBL4370025) |
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| EC50 | 200±n/a nM |
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| Citation |  Merlino, F; Billard, É; Yousif, AM; Di Maro, S; Brancaccio, D; Abate, L; Carotenuto, A; Bellavita, R; d'Emmanuele di Villa Bianca, R; Santicioli, P; Marinelli, L; Novellino, E; Hébert, TE; Lubell, WD; Chatenet, D; Grieco, P Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. J Med Chem62:1455-1467 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urotensin-2 receptor |
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| Name: | Urotensin-2 receptor |
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| Synonyms: | G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42725.34 |
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| Organism: | RAT |
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| Description: | Urotensin-II UTS2R RAT::P49684 |
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| Residue: | 386 |
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| Sequence: | MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSA
MGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGD
VGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLL
TLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWL
SQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNY
LTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSG
RSLSSSSQQATETLMLSPVPRNGALL
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| BDBM50517318 |
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| n/a |
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| Name | BDBM50517318 |
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| Synonyms: | CHEMBL4467241 |
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| Type | Small organic molecule |
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| Emp. Form. | C65H87N13O18S2 |
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| Mol. Mass. | 1402.593 |
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| SMILES | CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O |r| |
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| Structure | 
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