| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-8 |
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| Ligand | BDBM50517612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1869385 (CHEMBL4370451) |
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| IC50 | 46±n/a nM |
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| Citation |  Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, Y; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits. J Med Chem62:1626-1642 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-8 |
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| Name: | Proteasome subunit beta type-8 |
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| Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30357.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446797 |
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| Residue: | 276 |
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| Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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| BDBM50517612 |
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| n/a |
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| Name | BDBM50517612 |
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| Synonyms: | CHEMBL4577205 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H48N4O7 |
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| Mol. Mass. | 600.7461 |
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| SMILES | COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CCC2CCCCC2)C(=O)[C@@]2(C)CO2)cc1 |r| |
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| Structure | 
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