| Reaction Details |
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 | Report a problem with these data |
| Target | Alcohol dehydrogenase 1A |
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| Ligand | BDBM50518789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1872428 (CHEMBL4373595) |
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| IC50 | 5600±n/a nM |
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| Citation |  De Ford, C; Penchalaiah, K; Kreft, A; Humar, M; Heydenreuter, W; Kangani, M; Sieber, SA; Tietze, LF; Merfort, I Bifunctional Duocarmycin Analogues as Inhibitors of Protein Tyrosine Kinases. J Nat Prod82:16-26 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alcohol dehydrogenase 1A |
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| Name: | Alcohol dehydrogenase 1A |
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| Synonyms: | ADH1 | ADH1A | ADH1A_HUMAN | Alcohol dehydrogenase | Alcohol dehydrogenase 1A | Alcohol dehydrogenase alpha chain | Alcohol dehydrogenase subunit alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39866.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_31168 |
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| Residue: | 375 |
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| Sequence: | MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVT
PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNP
QGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG
YGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATE
CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ
NLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGF
DLLHSGKSIRTILMF
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| BDBM50518789 |
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| n/a |
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| Name | BDBM50518789 |
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| Synonyms: | CHEMBL4473548 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H30N2O4 |
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| Mol. Mass. | 494.5809 |
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| SMILES | C[C@@H]1CN(C(=O)CCCC(=O)N2C[C@@H](C)c3c2cc(O)c2ccccc32)c2cc(O)c3ccccc3c12 |r| |
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| Structure | 
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