Reaction Details |
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Target | D-3-phosphoglycerate dehydrogenase |
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Ligand | BDBM50519121 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1873878 (CHEMBL4375167) |
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IC50 | 2.0±n/a nM |
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Citation | Weinstabl, H; Treu, M; Rinnenthal, J; Zahn, SK; Ettmayer, P; Bader, G; Dahmann, G; Kessler, D; Rumpel, K; Mischerikow, N; Savarese, F; Gerstberger, T; Mayer, M; Zoephel, A; Schnitzer, R; Sommergruber, W; Martinelli, P; Arnhof, H; Peric-Simov, B; Hofbauer, KS; Garavel, G; Scherbantin, Y; Mitzner, S; Fett, TN; Scholz, G; Bruchhaus, J; Burkard, M; Kousek, R; Ciftci, T; Sharps, B; Schrenk, A; Harrer, C; Haering, D; Wolkerstorfer, B; Zhang, X; Lv, X; Du, A; Li, D; Li, Y; Quant, J; Pearson, M; McConnell, DB Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor J Med Chem62:7976-7997 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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D-3-phosphoglycerate dehydrogenase |
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Name: | D-3-phosphoglycerate dehydrogenase |
Synonyms: | D-3-phosphoglycerate dehydrogenase | PGDH3 | PHGDH | Phosphoglycerate dehydrogenase (PHGDH) | SERA_HUMAN |
Type: | Protein |
Mol. Mass.: | 56650.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 533 |
Sequence: | MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
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BDBM50519121 |
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n/a |
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Name | BDBM50519121 |
Synonyms: | CHEMBL4436264 | US11304929, Example 03-005 |
Type | Small organic molecule |
Emp. Form. | C21H20Cl2N2O5S |
Mol. Mass. | 483.365 |
SMILES | C[C@@H](NC(=O)c1cc2c(Cl)c(Cl)c(C)cc2n1C)c1ccc(cc1)S(=O)(=O)CC(O)=O |r| |
Structure |
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