Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM50519453 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1875440 (CHEMBL4376729) |
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IC50 | 38±n/a nM |
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Citation | Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, L; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia. ACS Med Chem Lett11:56-64 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM50519453 |
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n/a |
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Name | BDBM50519453 |
Synonyms: | CHEMBL4576056 |
Type | Small organic molecule |
Emp. Form. | C27H30FN3O5S |
Mol. Mass. | 527.608 |
SMILES | CN(CC(=O)N(Cc1ccc(cc1)C(C)(C)C)c1ccc(cc1)C(=O)NO)S(=O)(=O)c1ccc(F)cc1 |
Structure |
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