| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50519457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1875438 (CHEMBL4376727) |
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| IC50 | 187±n/a nM |
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| Citation |  Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, L; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia. ACS Med Chem Lett11:56-64 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50519457 |
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| n/a |
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| Name | BDBM50519457 |
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| Synonyms: | CHEMBL4452620 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N2O3 |
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| Mol. Mass. | 312.363 |
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| SMILES | CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)NO |
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| Structure | 
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