Reaction Details |
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Target | Interleukin-1 receptor antagonist protein |
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Ligand | BDBM50519952 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1878764 (CHEMBL4380158) |
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IC50 | >200000±n/a nM |
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Citation | Maben, Z; Arya, R; Rane, D; An, WF; Metkar, S; Hickey, M; Bender, S; Ali, A; Nguyen, TT; Evnouchidou, I; Schilling, R; Stratikos, E; Golden, J; Stern, LJ Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem63:103-121 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor antagonist protein |
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Name: | Interleukin-1 receptor antagonist protein |
Synonyms: | IL-1RN | IL1 inhibitor | IL1RA_MOUSE | IRAP | Il-1ra | Il1rn | Interleukin-1 receptor antagonist protein |
Type: | PROTEIN |
Mol. Mass.: | 20273.13 |
Organism: | Mus musculus |
Description: | ChEMBL_109596 |
Residue: | 178 |
Sequence: | MEICWGPYSHLISLLLILLFHSEAACRPSGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGY
LQGPNIKLEEKIDMVPIDLHSVFLGIHGGKLCLSCAKSGDDIKLQLEEVNITDLSKNKEE
DKRFTFIRSEKGPTTSFESAACPGWFLCTTLEADRPVSLTNTPEEPLIVTKFYFQEDQ
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BDBM50519952 |
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n/a |
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Name | BDBM50519952 |
Synonyms: | CHEMBL4454059 |
Type | Small organic molecule |
Emp. Form. | C20H22F3N3O5S |
Mol. Mass. | 473.466 |
SMILES | COc1ccc(cc1S(=O)(=O)Nc1cc(ccc1N1CCN(C)CC1)C(F)(F)F)C(O)=O |
Structure |
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