| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmic reticulum aminopeptidase 2 |
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| Ligand | BDBM50519953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1878765 (CHEMBL4380159) |
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| IC50 | >200000±n/a nM |
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| Citation |  Maben, Z; Arya, R; Rane, D; An, WF; Metkar, S; Hickey, M; Bender, S; Ali, A; Nguyen, TT; Evnouchidou, I; Schilling, R; Stratikos, E; Golden, J; Stern, LJ Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem63:103-121 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmic reticulum aminopeptidase 2 |
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| Name: | Endoplasmic reticulum aminopeptidase 2 |
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| Synonyms: | Aminopeptidase | ERAP2 | ERAP2_HUMAN | LRAP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 110463.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473169 |
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| Residue: | 960 |
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| Sequence: | MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE
RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA
TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY
KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK
TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL
QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD
KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV
CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ
YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT
WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI
HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV
GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE
NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES
SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL
IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG
TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
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| BDBM50519953 |
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| n/a |
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| Name | BDBM50519953 |
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| Synonyms: | CHEMBL2140832 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21F3N2O5S |
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| Mol. Mass. | 458.451 |
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| SMILES | COc1ccc(cc1S(=O)(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F)C(O)=O |
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| Structure | 
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