| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50074709 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72369 (CHEMBL680932) |
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| IC50 | 630±n/a nM |
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| Citation |  Ettmayer, P; France, D; Gounarides, J; Jarosinski, M; Martin, MS; Rondeau, JM; Sabio, M; Topiol, S; Weidmann, B; Zurini, M; Bair, KW Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J Med Chem42:971-80 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50074709 |
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| n/a |
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| Name | BDBM50074709 |
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| Synonyms: | (5S,8R,11S,14R,17R,22R,24aR)-17-Acetylamino-8-carbamoylmethyl-5,11-diisopropyl-4,7,10,13,16,24-hexaoxo-14-(4-phosphonooxy-benzyl)-docosahydro-19,20-dithia-3a,6,9,12,15,23-hexaaza-cyclopentacyclotricosene-22-carboxylic acid | CHEMBL367440 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H53N8O14PS2 |
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| Mol. Mass. | 916.955 |
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| SMILES | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](CC(N)=O)NC1=O)C(C)C)C(O)=O)NC(C)=O |
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| Structure | 
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