Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50074720 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_52990 (CHEMBL665259) |
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IC50 | 57.0±n/a nM |
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Citation | Rosowsky, A; Papoulis, AT; Forsch, RA; Queener, SF Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim. J Med Chem42:1007-17 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 23891.29 |
Organism: | Pneumocystis carinii |
Description: | n/a |
Residue: | 206 |
Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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BDBM50074720 |
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n/a |
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Name | BDBM50074720 |
Synonyms: | 6-(2,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | 6-(2,5-dimethoxybenzyl)-5,6,7,8-tetrahydroquinazoline-2,4-diamine | CHEMBL7375 |
Type | Small organic molecule |
Emp. Form. | C17H22N4O2 |
Mol. Mass. | 314.3822 |
SMILES | COc1ccc(OC)c(CC2CCc3nc(N)nc(N)c3C2)c1 |
Structure |
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