Ki Summary

Reaction Details

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Target

Somatostatin receptor type 2

Ligand

BDBM50075272

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_200682

8.5±n/a nM

Citation

Pasternak, A; Pan, Y; Marino, D; Sanderson, PE; Mosley, R; Rohrer, SP; Birzin, ET; Huskey, SE; Jacks, T; Schleim, KD; Cheng, K; Schaeffer, JM; Patchett, AA; Yang, L Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett9:491-6 (1999) [PubMed]

More Info.:

Get all data from this article, Assay Method

Somatostatin receptor type 2

Name:

Somatostatin receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41344.94

Organism:

Homo sapiens (Human)

Description:

P30874

Residue:

369

Sequence:

MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCG
NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT
VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY
AGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI
RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVL
TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTL
LNGDLQTSI

BDBM50075272

n/a

Name

BDBM50075272

Synonyms:

(2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3,3-diphenyl-propyl)-2-oxo-imidazolidin-1-yl]-3-(1H-indol-3-yl)-butyramide | CHEMBL148309

Type

Small organic molecule

Emp. Form.

C35H41N5O4

Mol. Mass.

595.7311

SMILES

C[C@H]([C@@H](N1CCN(CCC(c2ccccc2)c2ccccc2)C1=O)C(=O)NC[C@H]1OC[C@H](N)CO1)c1c[nH]c2ccccc12 |wU:2.2,28.30,wD:31.34,1.0,(-.69,3.24,;-.68,1.7,;.66,.93,;1.98,1.7,;1.97,3.24,;4.64,3.26,;4.65,1.72,;6,.97,;7.31,1.74,;8.66,.98,;9.99,1.77,;11.32,1,;12.65,1.77,;12.65,3.33,;11.29,4.08,;9.97,3.31,;8.66,-.56,;7.33,-1.33,;7.35,-2.87,;8.69,-3.62,;10.02,-2.83,;10.01,-1.31,;3.32,.95,;3.34,-.59,;.66,-.61,;2.2,-.61,;-.12,-1.94,;.64,-3.27,;-.14,-4.6,;.63,-5.93,;-.16,-7.26,;-1.7,-7.26,;-2.49,-8.57,;-2.45,-5.91,;-1.67,-4.58,;-2.01,.91,;-2,-.61,;-3.33,-1.41,;-4.66,-.64,;-6,-1.41,;-7.33,-.64,;-7.33,.91,;-6,1.68,;-4.66,.91,)|

Structure