| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome assembly chaperone 1/2 |
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| Ligand | BDBM50520988 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1882722 (CHEMBL4384221) |
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| IC50 | >250000±n/a nM |
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| Citation |  Ohsawa, K; Yoshida, M; Izumikawa, M; Takagi, M; Shin-Ya, K; Goshima, N; Hirokawa, T; Natsume, T; Doi, T Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer. Bioorg Med Chem26:6023-6034 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome assembly chaperone 1/2 |
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| Name: | Proteasome assembly chaperone 1/2 |
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| Synonyms: | PAC1-PAC2 complex |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1882722 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Proteasome assembly chaperone 1 |
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| Synonyms: | C21-LRP | C21LRP | Chromosome 21 leucine-rich protein | DSCR2 | Down syndrome critical region protein 2 | PAC-1 | PAC1 | PSMG1 | PSMG1_HUMAN | Proteasome assembly chaperone 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32855.57 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117168 |
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| Residue: | 288 |
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| Sequence: | MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEV
SLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAF
CVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSES
TGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVM
KLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT
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| Component 2 |
| Name: | Proteasome assembly chaperone 2 |
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| Synonyms: | HCCA3 | Hepatocellular carcinoma-susceptibility protein 3 | PAC-2 | PAC2 | PSMG2 | PSMG2_HUMAN | Proteasome assembly chaperone 2 | Synonyms=HCCA3 | TNFSF5IP1 | Tumor necrosis factor superfamily member 5-induced protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29396.28 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117168 |
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| Residue: | 264 |
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| Sequence: | MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNP
YATTEGNSTELSINAEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSGCARVIV
LSSSHSYQRNDLQLRSTPFRYLLTPSMQKSVQNKIKSLNWEEMEKSRCIPEIDDSEFCIR
IPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDALGLVEYLNEWLQILKPLSDDPTV
SASRWKIPSSWRLLFGSGLPPALF
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| BDBM50520988 |
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| n/a |
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| Name | BDBM50520988 |
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| Synonyms: | CHEMBL4435319 |
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| Type | Small organic molecule |
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| Emp. Form. | C53H58O17 |
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| Mol. Mass. | 967.0174 |
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| SMILES | COc1c(C)c(OC(=O)c2c(C)c(C)c(OC(=O)c3c(C)c(Oc4c(C)c(C)c(C(=O)Oc5c(C)c(C)c(C(O)=O)c(OC)c5C)c(OC)c4C)c(O)c(C)c3O)c(C)c2OC)c(C)c(C)c1C(O)=O |
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| Structure | 
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