| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50521013 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1882835 (CHEMBL4384334) |
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| EC50 | 600±n/a nM |
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| Citation |  Maschinot, CA; Chau, LQ; Wechsler-Reya, RJ; Hadden, MK Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. Eur J Med Chem162:495-506 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | Nr1i1 | Nuclear receptor subfamily 1 group I member 1 | VDR_MOUSE | Vdr | Vitamin D receptor | Vitamin D3 receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47830.18 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_491881 |
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| Residue: | 422 |
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| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRADVSTGSYSPRPTLSFSGDSSS
NSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFA
KMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDCGSQDYKYDITDVSRAGH
TLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQT
YIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNE
IS
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| BDBM50521013 |
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| n/a |
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| Name | BDBM50521013 |
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| Synonyms: | CHEBI:17933 | Calcifediol |
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| Type | Small organic molecule |
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| Emp. Form. | C27H44O2 |
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| Mol. Mass. | 400.6371 |
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| SMILES | [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)(C)O |
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| Structure | 
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