| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50076597 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106484 |
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| IC50 | 475±n/a nM |
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| Citation |  Freskos, JN; Mischke, BV; DeCrescenzo, GA; Heintz, R; Getman, DP; Howard, SC; Kishore, NN; McDonald, JJ; Munie, GE; Rangwala, S; Swearingen, CA; Voliva, C; Welsch, DJ Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett9:943-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50076597 |
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| n/a |
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| Name | BDBM50076597 |
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| Synonyms: | (R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-propane-1-thiol | CHEMBL368079 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16O3S2 |
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| Mol. Mass. | 260.373 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)C[C@H](C)CS |
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| Structure | 
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