| Reaction Details |
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 | Report a problem with these data |
| Target | Smoothened homolog |
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| Ligand | BDBM50522383 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1886540 (CHEMBL4388217) |
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| IC50 | >10000±n/a nM |
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| Citation |  Pace, JR; Teske, KA; Chau, LQ; Dash, RC; Zaino, AM; Wechsler-Reya, RJ; Hadden, MK Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. J Med Chem62:3873-3885 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Smoothened homolog |
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| Name: | Smoothened homolog |
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| Synonyms: | SMO_MOUSE | Smo | Smoh |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87472.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1510377 |
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| Residue: | 793 |
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| Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
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| BDBM50522383 |
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| n/a |
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| Name | BDBM50522383 |
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| Synonyms: | CHEMBL4556073 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H32Cl3N3O4 |
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| Mol. Mass. | 652.995 |
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| SMILES | C[C@@]1(OC[C@@H](COc2ccc(cc2)N2CCN(CC2)c2ccc(NC(=O)c3cccc(Cl)c3)cc2)O1)c1ccc(Cl)cc1Cl |r| |
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| Structure | 
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