| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM22774 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1889220 (CHEMBL4390974) |
|---|
| IC50 | 8800±n/a nM |
|---|
| Citation |  Calil, FA; David, JS; Chiappetta, ERC; Fumagalli, F; Mello, RB; Leite, FHA; Castilho, MS; Emery, FS; Nonato, MC Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase. Eur J Med Chem167:357-366 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | 1.3.5.2 | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41300.36 |
|---|
| Organism: | Schistosoma mansoni |
|---|
| Description: | ChEMBL_119667 |
|---|
| Residue: | 379 |
|---|
| Sequence: | MSRIRTSLEVLSLGFGLFTAEALYSGNEHFYKDWFLPTARLLVRDGETAHNLSVYLASYG
FIPHKQRNSFPQLKCKVFGLEFDHPIGLAAGFDKDGKAFMGLLNAGFSHIEVGTVTPNPQ
LGNARPRIFRWTEKEAVVNRCGFNSDGHDAVYERLKDRPWEGRGVIGVNLGCNKTSADPT
ADYVAGVRKFGEVADYLVINVSSPNTPGLRSLQTKEKLRDLLSKVLAARNQLSKKTPILL
KISPDENDQNLKDIVEVALDSKTRIDGMIISNTTLTTYEEAVACGAAPIPGNNKQNVVYG
GLSGRPLFEKSTDCLRKVSALTKGAIPLIGVGGISCGEDALSKLNAGASLVQLYTSFVYQ
GPPVAHKVAREINKLKMTS
|
|
|
|---|
| BDBM22774 |
|---|
| n/a |
|---|
| Name | BDBM22774 |
|---|
| Synonyms: | 1,4-Benzoquinone | Benzil-related compound, 53 | CHEMBL8320 | benzoquinone | cid_4650 | cyclohexa-2,5-diene-1,4-dione |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H4O2 |
|---|
| Mol. Mass. | 108.0948 |
|---|
| SMILES | O=C1C=CC(=O)C=C1 |c:2,6| |
|---|
| Structure | 
|
|---|
Search and Browse
