| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM50524482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1893570 (CHEMBL4395491) |
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| IC50 | 136000±n/a nM |
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| Citation |  De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. Eur J Med Chem175:63-71 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59724.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
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| Residue: | 536 |
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| Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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| BDBM50524482 |
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| n/a |
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| Name | BDBM50524482 |
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| Synonyms: | CHEMBL4460711 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H31NO4 |
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| Mol. Mass. | 289.4109 |
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| SMILES | CCCCCCCCCN1C[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1CO |r| |
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| Structure | 
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