| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4E |
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| Ligand | BDBM50525089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1895506 (CHEMBL4397541) |
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| Kd | 0.046000±n/a nM |
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| Citation |  Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G. J Med Chem62:4967-4978 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 4E |
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| Name: | Eukaryotic translation initiation factor 4E |
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| Synonyms: | EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 25095.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06730 |
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| Residue: | 217 |
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| Sequence: | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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| BDBM50525089 |
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| n/a |
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| Name | BDBM50525089 |
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| Synonyms: | CHEMBL4464315 |
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| Type | Small organic molecule |
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| Emp. Form. | C90H134N24O21 |
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| Mol. Mass. | 1888.1752 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| |
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| Structure | 
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