| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM5063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_202596 (CHEMBL806420) |
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| IC50 | 135000±n/a nM |
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| Citation |  Buchanan, JL; Vu, CB; Merry, TJ; Corpuz, EG; Pradeepan, SG; Mani, UN; Yang, M; Plake, HR; Varkhedkar, VM; Lynch, BA; MacNeil, IA; Loiacono, KA; Tiong, CL; Holt, DA Structure-activity relationships of a novel class of Src SH2 inhibitors. Bioorg Med Chem Lett9:2359-64 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
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| Type: | Protein |
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| Mol. Mass.: | 59838.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931 |
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| Residue: | 536 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM5063 |
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| n/a |
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| Name | BDBM5063 |
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| Synonyms: | 1,2,4-Oxadiazole Analogue 4i | 4-[(2S)-2-{[(1S)-3-carbamoyl-1-[3-(naphthalen-1-ylmethyl)-1,2,4-oxadiazol-5-yl]propyl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid | CHEMBL310313 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30N5O8P |
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| Mol. Mass. | 595.5403 |
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| SMILES | CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2cccc3ccccc23)no1 |r| |
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| Structure | 
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