Reaction Details |
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Target | Telomerase reverse transcriptase |
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Ligand | BDBM50080846 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_210087 |
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IC50 | >50000±n/a nM |
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Citation | Harrison, RJ; Gowan, SM; Kelland, LR; Neidle, S Human telomerase inhibition by substituted acridine derivatives. Bioorg Med Chem Lett9:2463-8 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Telomerase reverse transcriptase |
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Name: | Telomerase reverse transcriptase |
Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
Type: | PROTEIN |
Mol. Mass.: | 127099.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1447029 |
Residue: | 1132 |
Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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BDBM50080846 |
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n/a |
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Name | BDBM50080846 |
Synonyms: | 3,6-Bis[3-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octano)-propionamido)acridine | 3-(1,3,3-Trimethyl-6-aza-bicyclo[3.2.1]oct-6-yl)-N-{6-[3-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]oct-6-yl)-propionylamino]-acridin-3-yl}-propionamide | CHEMBL79536 |
Type | Small organic molecule |
Emp. Form. | C39H53N5O2 |
Mol. Mass. | 623.8704 |
SMILES | CC12CC(CC(C)(C)C1)N(CCC(=O)Nc1ccc3cc4ccc(NC(=O)CCN5CC6(C)CC5CC(C)(C)C6)cc4nc3c1)C2 |TLB:10:9:2:5.4.8,28:29:33:36.35.39| |
Structure |
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