| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-5 |
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| Ligand | BDBM50398609 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1901153 (CHEMBL4403375) |
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| IC50 | 3.4±n/a nM |
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| Citation |  Xi, J; Zhuang, R; Kong, L; He, R; Zhu, H; Zhang, J Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases. Eur J Med Chem182:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-5 |
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| Name: | Proteasome subunit beta type-5 |
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| Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
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| Type: | Protein |
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| Mol. Mass.: | 28480.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 263 |
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| Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
|
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|
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| BDBM50398609 |
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| n/a |
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| Name | BDBM50398609 |
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| Synonyms: | CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2238 | NINLARO |
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| Type | Small organic molecule |
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| Emp. Form. | C14H19BCl2N2O4 |
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| Mol. Mass. | 361.029 |
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| SMILES | CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O |
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| Structure | 
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