| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-gamma |
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| Ligand | BDBM50082041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_197217 (CHEMBL798965) |
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| EC50 | 42±n/a nM |
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| Citation |  Zacheis, D; Dhar, A; Lu, S; Madler, MM; Klucik, J; Brown, CW; Liu, S; Clement, F; Subramanian, S; Weerasekare, GM; Berlin, KD; Gold, MA; Houck, JR; Fountain, KR; Benbrook, DM Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem42:4434-45 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-gamma |
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| Name: | Retinoic acid receptor RXR-gamma |
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| Synonyms: | Nr2b3 | RXRG_MOUSE | Retinoid X receptor gamma | Rxrg |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50900.28 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_196589 |
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| Residue: | 463 |
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| Sequence: | MYGNYSHFMKFPTGFGGSPGHTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASSSHEDMPVERIL
EAELAVEPKTESYGDMNVENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDSFLMEMLETPLQIT
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| BDBM50082041 |
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| n/a |
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| Name | BDBM50082041 |
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| Synonyms: | 4-iminomethylphenyl 4,4-dimethyl-6-chromanecarboxylate,urea | CHEMBL341704 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O3S |
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| Mol. Mass. | 383.464 |
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| SMILES | CC1(C)CCOc2ccc(cc12)C(=O)Oc1ccc(C=NNC(N)=S)cc1 |w:20.22| |
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| Structure | 
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