Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50082925 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55105 (CHEMBL665365) |
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IC50 | 2500±n/a nM |
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Citation | Rosowsky, A; Cody, V; Galitsky, N; Fu, H; Papoulis, AT; Queener, SF Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain. J Med Chem42:4853-60 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 19884.75 |
Organism: | Mycobacterium avium |
Description: | Recombinant Mycobacterium avium DHFR expressed in E. coli. |
Residue: | 181 |
Sequence: | MTRAEVGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRP
LPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEV
TEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRP
S
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BDBM50082925 |
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n/a |
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Name | BDBM50082925 |
Synonyms: | 6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | CHEMBL423381 |
Type | Small organic molecule |
Emp. Form. | C19H15N7O |
Mol. Mass. | 357.3687 |
SMILES | Nc1nc(N)c2nc(CN3c4ccccc4Oc4ccccc34)cnc2n1 |
Structure |
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