| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50084133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_148685 (CHEMBL751059) |
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| IC50 | 26000±n/a nM |
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| Citation |  Alfaro-Lopez, J; Okayama, T; Hosohata, K; Davis, P; Porreca, F; Yamamura, HI; Hruby, VJ Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. J Med Chem42:5359-68 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50084133 |
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| n/a |
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| Name | BDBM50084133 |
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| Synonyms: | 3-[((R)-4-Benzyl-2-benzyloxymethyl-piperazin-1-yl)-(4-tert-butyl-phenyl)-methyl]-phenol | CHEMBL357746 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H42N2O2 |
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| Mol. Mass. | 534.7309 |
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| SMILES | CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)C[C@@H]1COCc1ccccc1)c1cccc(O)c1 |
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| Structure | 
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