Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50084205 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105959 (CHEMBL715372) |
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IC50 | 3±n/a nM |
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Citation | Cheng, M; De, B; Almstead, NG; Pikul, S; Dowty, ME; Dietsch, CR; Dunaway, CM; Gu, F; Hsieh, LC; Janusz, MJ; Taiwo, YO; Natchus, MG; Hudlicky, T; Mandel, M Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. J Med Chem42:5426-36 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50084205 |
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n/a |
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Name | BDBM50084205 |
Synonyms: | (R)-1-[4-(4-Fluoro-phenoxy)-benzenesulfonyl]-4-[(Z)-methoxyimino]-pyrrolidine-2-carboxylic acid hydroxyamide | CHEMBL421966 |
Type | Small organic molecule |
Emp. Form. | C18H18FN3O6S |
Mol. Mass. | 423.415 |
SMILES | CO\N=C1\C[C@@H](N(C1)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NO |
Structure |
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