Reaction Details |
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Target | Serine--tRNA ligase |
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Ligand | BDBM50530861 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1914051 (CHEMBL4416634) |
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IC50 | 9380±n/a nM |
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Citation | Cain, R; Salimraj, R; Punekar, AS; Bellini, D; Fishwick, CWG; Czaplewski, L; Scott, DJ; Harris, G; Dowson, CG; Lloyd, AJ; Roper, DI Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J Med Chem62:9703-9717 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine--tRNA ligase |
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Name: | Serine--tRNA ligase |
Synonyms: | 6.1.1.11 | SYS_ECOLI | SerRS | Serine--tRNA ligase | Seryl-tRNA synthetase | Seryl-tRNA(Ser/Sec) synthetase | serS |
Type: | PROTEIN |
Mol. Mass.: | 48404.41 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_117814 |
Residue: | 430 |
Sequence: | MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQ
AKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDN
VEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFM
LDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEV
PLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED
SMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCS
NVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLR
PYMNGLEYIG
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BDBM50530861 |
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n/a |
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Name | BDBM50530861 |
Synonyms: | CHEMBL4452350 |
Type | Small organic molecule |
Emp. Form. | C16H23N7O8S |
Mol. Mass. | 473.461 |
SMILES | C\C=C\c1nc(N)c2ncn([C@@H]3O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)CO)[C@@H](O)[C@H]3O)c2n1 |r| |
Structure |
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