| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Ligand | BDBM50088900 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_216859 (CHEMBL816696) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Missbach, M; Altmann, E; Widler, L; Susa, M; Buchdunger, E; Mett, H; Meyer, T; Green, J Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett10:945-9 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proto-oncogene tyrosine-protein kinase Src |
|---|
| Name: | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Synonyms: | Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src |
|---|
| Type: | Tyr protein kinase |
|---|
| Mol. Mass.: | 60015.36 |
|---|
| Organism: | Gallus gallus (Chicken) |
|---|
| Description: | P00523 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKL
FGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL
AHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHR
LTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG
TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ
GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
|
|
|
|---|
| BDBM50088900 |
|---|
| n/a |
|---|
| Name | BDBM50088900 |
|---|
| Synonyms: | 5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | 5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | CGP-62464 | CHEMBL169757 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14N4 |
|---|
| Mol. Mass. | 286.3306 |
|---|
| SMILES | Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
