| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50534162 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1927902 (CHEMBL4430974) |
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| Ki | 138±n/a nM |
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| Citation |  Brunschweiger, A; Koch, P; Schlenk, M; Rafehi, M; Radjainia, H; Küppers, P; Hinz, S; Pineda, F; Wiese, M; Hockemeyer, J; Heer, J; Denonne, F; Müller, CE 8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors. Bioorg Med Chem24:5462-5480 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
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| Type: | Protein |
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| Mol. Mass.: | 36704.13 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 326 |
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| Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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| BDBM50534162 |
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| n/a |
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| Name | BDBM50534162 |
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| Synonyms: | CHEMBL4556578 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19ClF3N5O2 |
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| Mol. Mass. | 441.835 |
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| SMILES | Cn1c2nc3CN(CCc4ccc(Cl)cc4C(F)(F)F)CCn3c2c(=O)n(C)c1=O |
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| Structure | 
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