| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50090538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71729 (CHEMBL680408) |
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| IC50 | 1.1±n/a nM |
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| Citation |  Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents. Bioorg Med Chem Lett10:1723-7 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37767.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1335047 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50090538 |
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| n/a |
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| Name | BDBM50090538 |
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| Synonyms: | 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea | CHEMBL296321 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33ClN4O3 |
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| Mol. Mass. | 509.04 |
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| SMILES | Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O |
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| Structure | 
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