| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Androgen receptor |
|---|
| Ligand | BDBM50535824 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1932232 (CHEMBL4477884) |
|---|
| IC50 | 49±n/a nM |
|---|
| Citation |  Bassetto, M; Ferla, S; Pertusati, F; Kandil, S; Westwell, AD; Brancale, A; McGuigan, C Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. Eur J Med Chem118:230-43 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Androgen receptor |
|---|
| Name: | Androgen receptor |
|---|
| Synonyms: | ANDR_RAT | Androgen receptor (AR) | Ar | Estrogen receptor | Nr3c4 | androgen |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98219.08 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P15207 |
|---|
| Residue: | 902 |
|---|
| Sequence: | MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQET
SPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAP
GKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQ
QQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVS
VSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTE
ETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDY
YNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPST
GSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFS
ASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQK
TCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLR
KCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVL
EAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVI
QYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWL
QITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFY
QLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
TQ
|
|
|
|---|
| BDBM50535824 |
|---|
| n/a |
|---|
| Name | BDBM50535824 |
|---|
| Synonyms: | CHEMBL4575144 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13F4N3O5 |
|---|
| Mol. Mass. | 427.3065 |
|---|
| SMILES | CC(O)(COc1ccc(C#N)c(F)c1)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
