| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 1 |
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| Ligand | BDBM50538549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1973134 (CHEMBL4605952) |
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| IC50 | >80000±n/a nM |
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| Citation |  Leger, PR; Hu, DX; Biannic, B; Bui, M; Han, X; Karbarz, E; Maung, J; Okano, A; Osipov, M; Shibuya, GM; Young, K; Higgs, C; Abraham, B; Bradford, D; Cho, C; Colas, C; Jacobson, S; Ohol, YM; Pookot, D; Rana, P; Sanchez, J; Shah, N; Sun, M; Wong, S; Brockstedt, DG; Kassner, PD; Schwarz, JB; Wustrow, DJ Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J Med Chem63:5398-5420 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 1 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 1 |
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| Synonyms: | Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48Â | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88191.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104169 |
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| Residue: | 785 |
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| Sequence: | MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
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| BDBM50538549 |
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| n/a |
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| Name | BDBM50538549 |
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| Synonyms: | CHEMBL4641424 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19ClN4O2 |
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| Mol. Mass. | 358.822 |
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| SMILES | Nc1cc(ccn1)-c1cc(Cl)cc2CC(Oc12)C(=O)N1CCNCC1 |
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| Structure | 
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