| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock protein 75 kDa, mitochondrial |
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| Ligand | BDBM50540232 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1981018 (CHEMBL4614280) |
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| IC50 | 8480±n/a nM |
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| Citation |  Jung, S; Yoon, NG; Yang, S; Kim, D; Lee, WS; Hong, KB; Lee, C; Kang, BH; Lee, JH; Kang, S Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock protein 75 kDa, mitochondrial |
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| Name: | Heat shock protein 75 kDa, mitochondrial |
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| Synonyms: | HSP75 | TRAP1 | TRAP1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80120.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1478164 |
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| Residue: | 704 |
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| Sequence: | MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFS
TQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA
SDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGS
KAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFE
IAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWM
MDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELG
SSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQL
TSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLR
EFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVT
LRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRAS
EPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH
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| BDBM50540232 |
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| n/a |
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| Name | BDBM50540232 |
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| Synonyms: | CHEMBL4641526 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N3O4S |
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| Mol. Mass. | 463.549 |
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| SMILES | CC(C)c1cc(-c2nnn(Cc3ccccc3)c2-c2ccc(cc2)S(C)(=O)=O)c(O)cc1O |
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| Structure | 
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