| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50096650 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106483 |
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| IC50 | 65±n/a nM |
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| Citation |  Chollet, AM; Le Diguarher, T; Murray, L; Bertrand, M; Tucker, GC; Sabatini, M; Pierré, A; Atassi, G; Bonnet, J; Casara, P General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors. Bioorg Med Chem Lett11:295-9 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50096650 |
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| n/a |
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| Name | BDBM50096650 |
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| Synonyms: | 2-(Biphenyl-4-yloxymethyl)-4-(2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-N-hydroxy-butyramide | CHEMBL100805 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N3O5 |
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| Mol. Mass. | 445.4672 |
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| SMILES | ONC(=O)C(CCn1c(=O)[nH]c2ccccc2c1=O)COc1ccc(cc1)-c1ccccc1 |
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| Structure | 
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