| Reaction Details |
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 | Report a problem with these data |
| Target | Apelin receptor |
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| Ligand | BDBM50541300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1984141 (CHEMBL4617547) |
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| EC50 | 290±n/a nM |
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| Citation |  Myers, MC; Bilder, DM; Cavallaro, CL; Chao, HJ; Su, S; Burford, NT; Nayeem, A; Wang, T; Yan, M; Langish, RA; Dabros, M; Li, YX; Rose, AV; Behnia, K; Onorato, JM; Gargalovic, PS; Wexler, RR; Lawrence, RM Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apelin receptor |
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| Name: | Apelin receptor |
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| Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42664.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35414 |
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| Residue: | 380 |
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| Sequence: | MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
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| BDBM50541300 |
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| n/a |
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| Name | BDBM50541300 |
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| Synonyms: | CHEMBL4642936 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O2S |
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| Mol. Mass. | 276.354 |
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| SMILES | CCCSc1nc(=O)cc(O)n1-c1cccc(C)c1 |
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| Structure | 
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