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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Apelin receptor | ||
| Ligand | BDBM50541306 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1984141 (CHEMBL4617547) | ||
| EC50 | 140±n/a nM | ||
| Citation |  Myers, MC; Bilder, DM; Cavallaro, CL; Chao, HJ; Su, S; Burford, NT; Nayeem, A; Wang, T; Yan, M; Langish, RA; Dabros, M; Li, YX; Rose, AV; Behnia, K; Onorato, JM; Gargalovic, PS; Wexler, RR; Lawrence, RM Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Apelin receptor | |||
| Name: | Apelin receptor | ||
| Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 42664.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35414 | ||
| Residue: | 380 | ||
| Sequence: |
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| BDBM50541306 | |||
| n/a | |||
| Name | BDBM50541306 | ||
| Synonyms: | CHEMBL4642418 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H18N2O2S | ||
| Mol. Mass. | 290.381 | ||
| SMILES | CCCSc1nc(=O)cc(O)n1-c1ccccc1CC |(20.85,-43.96,;22.19,-44.73,;23.52,-43.96,;24.85,-44.72,;26.19,-43.95,;26.19,-42.41,;27.52,-41.63,;27.52,-40.09,;28.86,-42.41,;28.86,-43.94,;30.19,-44.71,;27.52,-44.71,;27.52,-46.25,;26.19,-47.02,;26.19,-48.56,;27.52,-49.33,;28.86,-48.56,;28.86,-47.01,;30.19,-46.23,;31.52,-47,)| | ||
| Structure | 
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