| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM50097946 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_221659 (CHEMBL823236) |
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| IC50 | 400±n/a nM |
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| Citation |  Widler, L; Green, J; Missbach, M; Susa, M; Altmann, E 7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett11:849-52 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src |
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| Type: | Tyr protein kinase |
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| Mol. Mass.: | 60015.36 |
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| Organism: | Gallus gallus (Chicken) |
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| Description: | P00523 |
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| Residue: | 533 |
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| Sequence: | MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKL
FGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL
AHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHR
LTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG
TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ
GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM50097946 |
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| n/a |
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| Name | BDBM50097946 |
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| Synonyms: | 3-{4-Amino-7-[1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-phenol | CHEMBL169467 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N4O3 |
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| Mol. Mass. | 390.4351 |
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| SMILES | COc1ccc(CC(CO)n2cc(-c3cccc(O)c3)c3c(N)ncnc23)cc1 |
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| Structure | 
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